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ncbi reference sequence nm 020476  (OriGene)


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    OriGene ncbi reference sequence nm 020476
    Ncbi Reference Sequence Nm 020476, supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+reference+sequences/ANK1+(NM_020476)+Human+Tagged+ORF+Clone/pmc12269838-394-12-5
    Average 90 stars, based on 2 article reviews
    ncbi reference sequence nm 020476 - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    Mutagenesis:

    Article Title: Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant.
    Article Snippet: Cells were transiently transfected using Fugene HD (Promega), with a Fugene:DNA ratio of 3:1, for 24 hours. .. Plasmids harboring N-terminally myc-tagged wild-type or mutant human TDP-43 sequences (TARDBP, wild-type reference sequence NM_007375.3) were purchased from Origene. .. The presence of the A90V (c.269C>T) and M337V (c.1009A>G) mutations was confirmed by DNA sequencing performed by GENEWIZ (forward sequencing primer 5'-GGACTTTCCAAAATGTCG-3'; reverse sequencing primer 5’-ATTAGGA CAAGGCTGGTGGG-3’).

    Article Title: Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant
    Article Snippet: Cells were transiently transfected using Fugene HD (Promega), with a Fugene:DNA ratio of 3:1, for 24 hours. .. Plasmids harboring N-terminally myc-tagged wild-type or mutant human TDP-43 sequences ( TARDBP , wild-type reference sequence NM_007375.3) were purchased from Origene. .. The presence of the A90V (c.269C>T) and M337V (c.1009A>G) mutations was confirmed by DNA sequencing performed by GENEWIZ (forward sequencing primer 5'-GGACTTTCCAAAATGTCG-3' ; reverse sequencing primer 5’-ATTAGGACAAGGCTGGTGGG-3’ ).

    Sequencing:

    Article Title: Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant.
    Article Snippet: Cells were transiently transfected using Fugene HD (Promega), with a Fugene:DNA ratio of 3:1, for 24 hours. .. Plasmids harboring N-terminally myc-tagged wild-type or mutant human TDP-43 sequences (TARDBP, wild-type reference sequence NM_007375.3) were purchased from Origene. .. The presence of the A90V (c.269C>T) and M337V (c.1009A>G) mutations was confirmed by DNA sequencing performed by GENEWIZ (forward sequencing primer 5'-GGACTTTCCAAAATGTCG-3'; reverse sequencing primer 5’-ATTAGGA CAAGGCTGGTGGG-3’).

    Article Title: Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant
    Article Snippet: Cells were transiently transfected using Fugene HD (Promega), with a Fugene:DNA ratio of 3:1, for 24 hours. .. Plasmids harboring N-terminally myc-tagged wild-type or mutant human TDP-43 sequences ( TARDBP , wild-type reference sequence NM_007375.3) were purchased from Origene. .. The presence of the A90V (c.269C>T) and M337V (c.1009A>G) mutations was confirmed by DNA sequencing performed by GENEWIZ (forward sequencing primer 5'-GGACTTTCCAAAATGTCG-3' ; reverse sequencing primer 5’-ATTAGGACAAGGCTGGTGGG-3’ ).

    Article Title: Identification of an ATP-sensitive potassium channel in mitochondria
    Article Snippet: .. MITOSUR expression plasmid (pCMV6-ABCB8-myc-Flag), containing the NM_007188 reference sequence (and corresponding to ABCB8 transcript variant 2), was purchased from Origene (cat no RC224948). ..

    Article Title: Identification of an ATP-sensitive potassium channel in mitochondria.
    Article Snippet: .. MITOSUR expression plasmid (pCMV6-ABCB8-myc-Flag) containing the NM_007188 reference sequence (and corresponding to ABCB8 transcript variant 2) was purchased from Origene (cat no RC224948). ..

    Expressing:

    Article Title: Identification of an ATP-sensitive potassium channel in mitochondria
    Article Snippet: .. MITOSUR expression plasmid (pCMV6-ABCB8-myc-Flag), containing the NM_007188 reference sequence (and corresponding to ABCB8 transcript variant 2), was purchased from Origene (cat no RC224948). ..

    Article Title: Identification of an ATP-sensitive potassium channel in mitochondria.
    Article Snippet: .. MITOSUR expression plasmid (pCMV6-ABCB8-myc-Flag) containing the NM_007188 reference sequence (and corresponding to ABCB8 transcript variant 2) was purchased from Origene (cat no RC224948). ..

    Plasmid Preparation:

    Article Title: Identification of an ATP-sensitive potassium channel in mitochondria
    Article Snippet: .. MITOSUR expression plasmid (pCMV6-ABCB8-myc-Flag), containing the NM_007188 reference sequence (and corresponding to ABCB8 transcript variant 2), was purchased from Origene (cat no RC224948). ..

    Article Title: Identification of an ATP-sensitive potassium channel in mitochondria.
    Article Snippet: .. MITOSUR expression plasmid (pCMV6-ABCB8-myc-Flag) containing the NM_007188 reference sequence (and corresponding to ABCB8 transcript variant 2) was purchased from Origene (cat no RC224948). ..

    Variant Assay:

    Article Title: Identification of an ATP-sensitive potassium channel in mitochondria
    Article Snippet: .. MITOSUR expression plasmid (pCMV6-ABCB8-myc-Flag), containing the NM_007188 reference sequence (and corresponding to ABCB8 transcript variant 2), was purchased from Origene (cat no RC224948). ..

    Article Title: Identification of an ATP-sensitive potassium channel in mitochondria.
    Article Snippet: .. MITOSUR expression plasmid (pCMV6-ABCB8-myc-Flag) containing the NM_007188 reference sequence (and corresponding to ABCB8 transcript variant 2) was purchased from Origene (cat no RC224948). ..



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    Image Search Results


    Schematic overview of training and inference workflows. A) Training phase: Positive and negative sample pairs are processed through the embedding module to generate four modality-specific embedding representations, human/virus sequence embedding is encoded by ESM-2 to represent amino acid sequence features, human/virus chemical embedding is extracted from AAindex profiles to represent protein biochemical properties. The cross-fusion module computes loss via contrastive learning and executes forward propagation. Model parameters are iteratively updated using the Adam optimizer, with final weights preserved for inference. B) Binary task inference. Pre-trained weights are loaded to compute task-specific losses, enabling downstream classification prediction. C) Conditional generative inference. A sequence decoder module translates fused modality embeddings into human protein sequences, with outputs ranked to return the top five highest-confidence matches.

    Journal: Biosafety and Health

    Article Title: DeepHVI: A multimodal deep learning framework for predicting human-virus protein-protein interactions using protein language models

    doi: 10.1016/j.bsheal.2025.07.005

    Figure Lengend Snippet: Schematic overview of training and inference workflows. A) Training phase: Positive and negative sample pairs are processed through the embedding module to generate four modality-specific embedding representations, human/virus sequence embedding is encoded by ESM-2 to represent amino acid sequence features, human/virus chemical embedding is extracted from AAindex profiles to represent protein biochemical properties. The cross-fusion module computes loss via contrastive learning and executes forward propagation. Model parameters are iteratively updated using the Adam optimizer, with final weights preserved for inference. B) Binary task inference. Pre-trained weights are loaded to compute task-specific losses, enabling downstream classification prediction. C) Conditional generative inference. A sequence decoder module translates fused modality embeddings into human protein sequences, with outputs ranked to return the top five highest-confidence matches.

    Article Snippet: Since model-generated sequences may not correspond to natural proteins, we retrieved 20,078 human reference protein sequences from National Center of Biotechnology Information (NCBI) (accession: GCF_000001405.40) and 17,451 reviewed viral protein sequences from UniProt Swiss-Pro (taxon ID 10239) to ensure biological relevance.

    Techniques: Virus, Sequencing

    Cosine similarity analysis of generated human protein sequences and viral protein sequences. A) Cosine similarity between generated and ground-truth human proteins, illustrating the distribution of cosine similarity values between human protein sequences. B) Cosine similarity between generated and ground-truth viral proteins, depicting the distribution for viral protein sequences, which exhibits slightly lower and more variable similarity scores. In both cases, the distributions are sharply peaked around 0.8, indicating a generally strong semantic alignment across samples. Human and viral protein sequences from the test set were analyzed using DeepHVI to generate a density distribution of similarity scores between reconstructed sequences and human interactors. Abbreviations: Std, standard deviation; Min, minimum; Max, maximum.

    Journal: Biosafety and Health

    Article Title: DeepHVI: A multimodal deep learning framework for predicting human-virus protein-protein interactions using protein language models

    doi: 10.1016/j.bsheal.2025.07.005

    Figure Lengend Snippet: Cosine similarity analysis of generated human protein sequences and viral protein sequences. A) Cosine similarity between generated and ground-truth human proteins, illustrating the distribution of cosine similarity values between human protein sequences. B) Cosine similarity between generated and ground-truth viral proteins, depicting the distribution for viral protein sequences, which exhibits slightly lower and more variable similarity scores. In both cases, the distributions are sharply peaked around 0.8, indicating a generally strong semantic alignment across samples. Human and viral protein sequences from the test set were analyzed using DeepHVI to generate a density distribution of similarity scores between reconstructed sequences and human interactors. Abbreviations: Std, standard deviation; Min, minimum; Max, maximum.

    Article Snippet: Since model-generated sequences may not correspond to natural proteins, we retrieved 20,078 human reference protein sequences from National Center of Biotechnology Information (NCBI) (accession: GCF_000001405.40) and 17,451 reviewed viral protein sequences from UniProt Swiss-Pro (taxon ID 10239) to ensure biological relevance.

    Techniques: Generated, Standard Deviation